I'm going to say no to Nathan Hale and Drake, they don't have any physically defining features that make them iconic EDIT: AND they've only been in one game each so far that hasn't been HUGE (FF7 huge), that will change when the sequels come.
I'm going to say (in addition to what axumblade listed), Crash Bandicoot(PS1), Cloud and Sephiroth from FF7 (PS1) and Solid Snake (PS1, PSP, PS2, PS3), Dante (PS2)







