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My top recommendations would be Gears of War, Mass Effect, and Braid. If at all possible, make sure you check out the split-screen co-op in Gears - in my opinion, it's what elevates the title from "good" to "masterpiece". I'd also recommend BioShock, but you might as well wait an additional month and see how the PS3 version turns out.

The Orange Box is also an incredible value. However, it really is best experienced on the PC. If your PC is absolutely incapable of running it, the 360 version is worth getting as an alternative.