Ohhhh I see. The first one that comes to mind is dragonball if that counts. Although a few others like Chrono Trigger and Dragonquest has a similar artsyle I can still tell all the characters a part. I always thought a few final fantasy characters like Cloud and Sephiroth was pretty well designed. Even FFXIII I thought did a pretty decent job with a few characters. The picture in your avatar as well. Although i dont know who he is he still stands out to me. This is typically speaking from someone who knows very little about anime so Im sure there is tons of others that are unique and that stands out.
OK. I can see where you're coming from but there are a lot of JRPGs with more original designs that don't sell a whole lot still...see the Baten Kaitos series :/
In any case, most JRPG characters don't look like the ones in this series.
Yes, PS3 exclusive.