Well, if you're already on board with this concept, surely you must agree that having almost human like game characters will turn people off? Even if UC has a stylized design, they're trying to emulate real life objects. Gears of War, on the other hand, do not risk getting too realistic imo. compare these two imagies:
-Uncharted 3 pic
-Gears of War 3 pic
Clearly, UC is giong for a more realistic look on Drake, rather than what's been done with Fenix; he's a lot more... cartoony. Well, maybe not a lot :P And going the way of UC is the wrong path imo...
I would argue that Gears of War was trying to look more realistic than Uncharted, and that pic of Drake is art, not an in-game shot. In fact, boh of those pics are. Uncharted isn't a very good example anyway, because its characters have never repulsed anyone. It's very stylized.
Very few games fall into that category, VERY few, but the ones that did, for the most part, were highly successful (Heavy Rain, Mass Effect as examples). Besides, it can't be "the wrong path" until it proves a detriment.