After part 3 they can only go backwards or inbetween, However I fear for the starwars prequel effects

I hope this is for next gen though if there going to use the Frostbite engine.

The only thing that worries me about this post is that it hasn't started development yet. God dam I cant wait for mass effect 4. The worse thing in the world would be a spin off but to answer the question definitely a sequel. not sure what time frame, I think they should surprise us on that

Great idea, i think that would be perfect

I say several hundred years in the future, they will have to select one of the endings as cannon, but we will get over it

I just want more Mass Effect, I really liked the universe and so any more chance to explore it would be appreciated.

This may sound weird, but I also want a Star Wars Empire at War (similar to Total War, but in space) style RTS

no

No prequel please no prequel. A space Odysey would be cool. Because I really doubt they can top the threat the Reapers represented. But lets be honest story wise was Bioware always pretty. I would personally would like a few Gameplay changes. Some Human Revolution elements would be cool.

They could take it to any time and place and it would be badass. New characters are 100% welcome for me.

This! I don't care what they do as long as they keep making Mass Effect games!