I don't really think many of the games people are throwing around here will bomb, games like ME3, AC3 and such are multi-platform ports they are dirt cheap to make and release so even the 300k units someone earlier predicted will generate a large amount of money however I'm sure the games will sell more then that. I can only really see below the radar games like Tank Tank Tank and Wonderful 101 bombing in their sales.
The reason being is that although the online forum groups believe the Wii following won't go for certain games the actual situation is that unlike the Wii most third parties are trying to make their presence known from the start as opposed to ignoring them or not approaching with the same dedication as other gaming groups, a number of the Wii following will buy the games when they see them advertised as COD and Monster Hunter showed.