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N64 had a devastating impact on Nintendo's home consoles by:

1. Primarily being the reason the PS1 existed, and
2. Flocking away third party support.

The Wii U though was a failure as a console PERIOD. Probably the worst branded console in history and failed to really do anything apart from inspiring the Switch concept.

And that's where it's tough. Without the Wii U, I doubt the Switch would exist. Without the N64 (and all the decisions that went to making it), Sony might've not entered the gaming market for another generation or two, and Nintendo might've dominated the next few cycles.

It has to be between those two imo. Wii U is by far the worst console on the list but the N64 impacted Nintendo so badly, you still feel the repercussions today.