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Torillian said:

Never played Bayonetta all the way through but you're obviously right since they have all those angel enemies.  I guess Binding of Isaac just crossed a fairly liberal line.  That said, even that line should probably be taken out.  Let the consumer decide if it's something they don't want.

It sounds arbitrary, but I think they probably differentiate between dealing with religion in the somewhat fantastical way a lot of JRPGs do (including Nintendo's own Xenoblade, I'd imagine, if it's anything like the rest of the Xeno games) and doing so in a more pointed, satirical way like Binding of Isaac.