NES: Duck Hunt
SNES: Super Mario World
N64: Donkey Kong 64
Game Boy: Pokemon red/blue/yellow
PS2: GTA San Andreas / GT3
Game Cube: Wind Waker
Wii: Super Mario Galaxy (1 & 2)
DS: Professor Layton (series)
PS3: Assassins Creed 2 (and its sequels)
3DS: Super Mario Land
PC: diffcult one cconsidering it has a much longer cycle. but if I had to choose, FM 2004 adn Red Alert 2