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MontanaHatchet said:
Resident Evil 4, in my experience, is a game you can pick up and play easily. Zack & Wiki takes devoted play time.

Both are good.

 You know, I find the very opposite to be true.  Zack and Wiki can be played in small doses, a level at a time.  Something like RE4 requires you to sink in some time, especially if you play like me at turtle speed making sure there are no zombies around teh next corner.

 

While I love Zack and Wiki, I would have to go with RE4.  Something just tells me you are getting a little more for your money in RE4.  I whole-heartedly support Zack and Wiki, but that has a lot to do with the fact that I think we should support crazy games as much as possible.