Sonic the Hedgehog 2, along with Sonic & Knuckles had some awe inspiring final bosses. Using the master emerald to power a giant laser beam = hide in corner.
Ganon from Ocarina of Time is also another unforgettable boss. I mean... wow. What a way to end a game.
Metroid Prime, with the Omega Pirate, Meta Ridley, and Metroid Prime... all amazing.
Okami had some great bosses as well. Especially memorable was Ninetails... I thought I was the only one capable of using a celestial brush!
Twilight Princess' final battle was also fantastic. Ganondorf has been cemented as my favorite villain of all time.
And I can't forget your first encounter with Meta Ridley in Corruption. It's like Metroid meets LotR, and it was amazing.
Oh, and I have to give credit to Suda51 for his insane bosses in No More Heroes. All of them were so... mind blowingly awesome. 
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