So, name me a time when your blood pressure went into the danger zone when playing a game. For me there have been two recently:

Wipeout HD - After one hour of trying to beat Zico, I fell short of the lap time by 0.08 seconds. I was like 'AHHHHHHHHHHH'

COD:WAW - Try Heart of the Reich on Veteran. It nearly killed me. Surrounded by 10 grenades constantly and with a never ending supply of enemies charging at you until you reach a certain part of the level, its fucked up. I was almost in tears, but I managed to do it. Also in the game I was trying to get 'the sum of all zeros' trophy and I fell short by 3 planes. Again, I was mad.

So what's your stressful moments?  And can I suggest some remedies - When you get stressed have a coffee, put your feet up and most importantly play Flower off the PSN (If you can obviously). If your a smoker Im sure a cig does the calming job too.

losing in one of the last races in F-Zero GX's story mode on hard difficulty by a fraction of a second.

and many more from that game.

CoD-WaW is a big one. I died once because after I threw back 6 consecutive grenades, I still had 4 in my feet O_o

GTAIV when I accidentally deleted my 100% save file

Yep, COD:WAW is a death bringer, honestly.

Id also say the Old GTA games were terrible. I mean you put hours into a session, then all of a sudden it freezes.

Little Big Planet- After having to restart the entire level, over, and over, and over, and over.... =( I suck at performers.

LBP was easy

I also thought MGS4 was stressful. It took me ages to figure out how to kill Screaming Mantis

Definitely CoD:WaW and Dead Space on impossible difficulty.

Raam in Gears of War. That motherfucker was relentless and the Kryll would always kill me when I tried to hide.

Vagrant Story on the PS1 was the source of many hair pulling moments, too.

When I was a kid, playing Battletoads on the NES...I must´ve broken about 4 controllers because of that game.

EVERY Call of Duty on Veteran is getting my blood pressure to 22.
But CoDMW's Mile High Club, was absolutely the most frustrating thing I've ever done.
I chilled down a bit after that. No need to play every game on extreme difficulty...