Here's a more accurate top 30. I used Alacrist's Wikipedia numbers when they were higher than VGC's count of million-sellers-only, and vice versa, and added a bunch of franchises with numbers derived from VGC's list. I also added pack-in titles with an asterisk, and consolidated the various Tom Clancy brands from the original list. I also rounded numbers and left franchises with similar sales on the same spot on the list, since there's a ton of guesswork anyways. I cut Lineage from the list, since we know 43 million is too high. Lastly, I threw in numbers for some non-million seller games where I thought of it; for example, the sales of Diddy Kong Racing DS ought to push the DK franchise above 50 million, and sales of Spiderman 3 push that franchise to at least the 17 million mark.
1. Mario 282 million *including pack-ins (~200 w/o pack-ins; >300 w/ pack-ins and spin-offs like Yoshi and Wario.)
2. Pokemon 155 million
3. Sim 85 million
4. Final Fantasy 75 million
5. Grand Theft Auto 59 million
6. Madden NFL 56 million
7. Donkey Kong 50 million
7. Zelda 50 million
9. Tetris 46 million *including pack-in
9. Gran Turismo 46 million
11. Tom Clancy 44 million
11. Sonic 44 million
13. Dragon Quest 41 million
14. Star Wars 39 million
15. Need For Speed 36 million
16. Crash Bandicoot 34 million
17. Resident Evil 31 million
18. James Bond 007 30 million
18. Tomb Raider 30 million
20. Duck Hunt 28 million *including pack-in
21. Mega Man 27 million
22. Command and Conquer 25 million
22. Street Fighter 25 million
24. Tekken 24 million
24. Kirby 24 million
26. Mortal Kombat 20 million
27. Warcraft 19 million
27. Rayman 19 million
29. Metal Gear 18 million
30. 5 series with at least 17 million: Spyro, Winning Eleven, Diablo, Medal of Honor, Spiderman
Franchises including Tony Hawk, Harry Potter, FIFA and others would likely make the list with more complete numbers.