"why do you keep touching me" - Warcraft II
And an endless amount from Disgaea: Hour of Darkness

"The destruction of the Philadelphia was not an accident. It was a merciful bullet to the head of a malignant ideology. It was the death of fear and the birth of hope. Rejoice, children of Nod, the blood of your oppressors will flow and fifty years of tyranny will finally end. Transformation is coming. A new day will dawn. The future... is ours." - Kane

Kane always has the best quotes from Command & Conquer 

Ryu: I will get my revenge!

Ryu: I get two kinds of payment. The first I have already received.
The second...is you, Foster!

(Ninja Gaiden NES)


"I will destroy everything! I will create a monument to non-existence!" -Kefka

"Nothing can beat the music of hundreds of voices screaming in unison." -Kefka

(Final Fantasy 6 SNES)


The black wind begins to blow... -Magus

Azala: The Future....
Ayla: What about future?
Azala: We have....no future...

(Chrono Trigger SNES)


"Grant unto thee the great power of the glorious mother of destruction!" -Grahf (Xenogears PS)

Melding with the Planet... I will cease to exist as I am now... Only to be reborn as a 'God' to rule over every soul. -Sephiroth (Final Fantasy VII PS)

"Metal Gear, it can't be! " -Snake (MGS PS)

"Now let me read your mind - Psycho Mantis (MGS PS)

"Snake, history will never know what she did. Her story, her debriefing, will endure only in your heart - She was a real hero. She was a true patriot." - Eva (MGS3 PS)

"this pizzeria is no push over"- San Andreas

"I like to walk down mainstreet in women panties and eat donuts"- Vice City

"All your bases are belong to us"...

"that guy is so out of my top 8" Ratchet and Clank ToD

"I am matter.
I am Antimatter.
I can see the past.
I can see the Future
I consume time.
and I will consume you!!!"

-Culex, from Super Mario RPG-

Duke Nukem FTW!

Also, Lo Wang from Shadow Warrior has many unforgettable lines...

"Ha ha! You blocking with your head again!" 

“Is this all there is …… no challenge ……. No resistance” - Black Knight
Fire Emblem: Path of Radiance

"Look behind you, a three-headed monkey!"

"How appropriate, you fight like a cow"

(Monkey Island)

____________________ 

"You know what they say: 'To save the world, you have to push a few old ladies down the stairs.' " 

 (Day of the Tentacle)

"Wipe this pathetic planet from the face of the galaxy!"--Darth Malak, KotOR 1

Baldur's Gate 2.

There is no game on the face of this Earth that has more awesome quotes.

Anyone who disagrees is wrong.