Uncharted: Drake's Fortune was based around the historical figure of Sir Francis Drake and re-tracing some of his explorations/adventures.
Uncharted 2: Among Theives was based around the historical figure of Marco Polo and re-tracing some of his explorations and adventures.
So the key question for Uncharted 3 is not where Drake should go, but who's path of adventure / exploration he should re-trace.
He's done an English explorer and an Italian explorer so far. Being a bit Eurocentric in theme to date there are Spaniards and Portuguese explorers to consider, and there are Dutch and Belgian explorers. There's also the Vikings, who were realy the first Europeans to reach North America, they just didn't realise what they'd found so didn't actively seek to colonise it.
Personally I like the idea of Drake (and Elena and Chloe - gotta keep that love triangle going) getting into the machinations of King Leopold II of Belgium, in relation to the Congo. This particularly nasty tale heavily involves H M Stanley, who coincidentally is the person who is attributed with the famous line "Dr. Livingstone, I presume", which happens to bring the whole quest for the source of the Nile adventure into the frame, and with the Nile being part of the tale this brings Egypt into play and that gives us the pyramids which come with mummies (though don't want too much focus on mummies, what with those Brendan Fraser movies hvaing already been there). As the Congo is approximately 30% of the worlds diamond reserves, it's pretty obvious where the "treasure" angle would come from.
A gigantic African romp throughout the Congo, up (or down) the Nile, through the great Rift Valley, all sorts of supernatural possibilities, political corruption and intrigue surrounding diamonds ranging from the African warlords and banana republics, through to big business in Europe and America, and throw in Ebola virus for good measure. It could all start with Drake trying to put a big old diamond ring on Elena's finger, and it all going wrong from there.
Who do you favour as the adventurer/explorer for Drake to follow?
“The fundamental cause of the trouble is that in the modern world the stupid are cocksure while the intelligent are full of doubt.” - Bertrand Russell
"When the power of love overcomes the love of power, the world will know peace."
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