I can't see portable gaming replacing home gaming for another decade or too. One major feature that would be lost is multiplayer, local would be impossible unless an owner owned multiple systems. This is financially impossible for most consumers who can't afford multiple consoles. Then lets not forget screen size, handhelds screens would just be to small to satisfy the average gamer. So any future handheld would also need TV connectivity so that the consumer could play on a big screen. But then the game would need multiple resolutions as stretching out that small crystal clear image onto a 42 inch would be nearly impossible to do without sacrificing quality.
I think it might happen eventually, when the Matrix or Holograpms become a reality. But not within the next ten years!