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Shenmue (If it still counts) I bought the original Xbox mainly for Shenmue 2. Salty Sega killed the franchise by releasing the sequel on the wrong platform. Sucks that Kickstarter Shenmue 3 isn't shaping up as well as I had hoped but I don't regret contributing.

Doom 3, Soul Calibur, and Tales of Vesperia (PS3 version is Japan exclusive) also come to mind.