Im currently using Dolphin emulator, never used it before, to play my GC and Wii backups ;) and i cant believe how good games look on this thingy. Having all the Wii/GC library and running them at 60fps/1080p with really upgraded filtering antialiasing anisotropy etc. is just a godsend.
For me is the best gaming experience ive had since...ever.
Of course i use a gamepad instead of keyboard (except for those Wii games that require it, in which case the mouse works fine).
Sure you need a really powerful PC to run it at this level but still..is just a plus, and a big one.
My PC is: CPU i7 2600k 3.4 ; GTX 650 Ti Boost 2GB which is basically a GTX660 and 8 GB RAM at 1666