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deskpro2k3 said:
so can i do a rig with an AMD cpu and a nvidia graphic card? any downside with that combination?

Sure thing, nothing stopping anyone from doing that yet ... 

Unless of course one day every hardware vendor decides to do lock-in like only allow single setup pairings such as AMD CPU/AMD dGPU, Intel CPU/Intel dGPU or Nvidia preventing it's drivers from working on either CPU vendors ...