Motion blure and depth of field are two that I have to keep an eye on. Sometimes a game makes me feel sick or gives me a headache and scaling those back helps. Bloom can certainly be annoying but rarely does it cause me real problems.
Not a graphical effect but I'm not a fan of rumble in most instances. It's very seldom immersive and usually the opposite.
Lens flare and God rays are sometimes way overused. I often turn them off or down.
Shooting a mind beam at his horse?