Defend the most. Probably the Final Fantasy games in the Golden Ara and Suikoden series. Best FF game is Final Fantasy 10, and I defend that with all my honor. And in Suikoden, I adore Suikoden 2. I love my good TB-JRPG's!
This generation though.. Probably MGS4 and Uncharted 1 (best in the franchise). My favorite franchise FF though hasn't come out with anything even decent, as FF13 blew. They totally forgot how to make a FF game that the fans want. I don't defend future games blindly, just the good ones. And in the other corner, they haven't made a real Suikoden game since the PS2, so I am out of luck on this one.