No, the best the Vita can do is sustain itself and make a nice profit for Sony, but I doubt it's going to beat anyone. If Nintendo get desperate then they could easily drop the price down to $150, re-design the console, release some Mario game and then ride on that for a while. If that doesn't work, then maybe.
Bet with Conegamer and AussieGecko that the PS3 will have more exclusives in 2011 than the Wii or 360... or something.