Uncharted 3. but Killzone 3 could be in with a shot.
and the Last Guardian is the dark horse is this list, because it will sell more than any of those games in Japan, so worldwide totals could end up being the highest; i doubt it because it dosent have seem to have mass market appeal like Uncharted here in the west. but i think it could do really good numbers if its marketed well.
and i would like to see Twisted Metal do really well, but not sure how well recieved it will be. it could be a record high for the series because of a lot of the new features we've been shown. and hopefully Infamous 2 does really well as well; might pick it up myself!!