In the 80's, there was a shitty movie called Gymkata. There was a scene where the main character was in a town full of canibals, and everone in the city wanted a bite of his ass. The scene was horrifying and hopeless, and the sole reason I remember that otherwise forgettable film. RE4's beginning let me live that scene. Do anything you can to survive that hopeless situation. Barricade doors. Climb ladders, towers, and roof tops. Run! No hope, because nothing can stop your resourceful enemies.
I was a great adrenaline rush, and in my opinion, flawlessly done. It really set the mood. Combined with the scene where Luis, Ashley, and Leon are barricaded in the cabin, you just convinced me to replay the game again!