A few more clues

Current list - https://gamrconnect.vgchartz.com/thread.php?id=249858&page=1#6

49 - Super Street Fighter II
- There could be up to 4 previously unvisited countries on your itinerary.
- England, Mexico, Jamaica, Hong Kong

46 (incorrect guesses - Psychonauts)
- The playable character has the ability to enter people's dreams
- This was sort of like the PS1’s answer to classic Zelda.

45
- You end up trying to solve everyone's problems whilst trying to solve your own.
- Both this title and its sequel took advantage of the features of the hardware it was released on - you even have to hold the console like a book to enhance the visual novel aspect of the game.

42
- Pink or blue - you will see one of these colours when you complete a level.
- The two playable characters from the first game in the series must be saved.

40
- Obtaining the collectibles in this direct sequel is not quite as frustrating as the first game in the series.

39
- In some regions, this game had the same title as two other games in this well known series. In other regions, it had a subtitle.

More clues.

#40

• One of this game's side characters is likely the Finnish god of water, though it's never explicitly confirmed.
• Hiss
• The Oldest House

#39 Monster Hunter World

• The highest-selling game in this long-running series focused on killing monsters.

#38 Tales of Berseria

• A remaster of this action RPG was just announced less than a week ago.

#37

• Drangleic
• Vendrick
• Nashandra

#36 Fire Emblem: Three Houses

• Pick your side, black, blue, or gold.

More hints!

#40 - The genius behind this 2005 game is working on something new, first teased during The Game Awards last year.

#39 - England, Mexico, Jamaica, Hong Kong.

#38 - With this acclaimed game, Nintendo borrowed Rare's brilliant idea of putting big googly eyes on inanimate objects.

#37 - "No glib remark? No pithy comeback?

#36 - Before he soared through the skies in makeshift airships, he sailed the seas in this game

I just realized I used the same clue as you!  

Haha, yes. In the same order as well. I'll leave that one for someone else, although I may class you as solving my clue.

However, I'd guess 37 is GoldenEye, and 36 is Wind Waker?

Correct on both!

39: Super Street Fighter 2: The new challengers? (For Cammy, T. Hawk, Dee Jay and Fei Long stages)

#40: This game series from Stardock got often called a successor to Master of Magic, here in it's third iteration.

1. It's the technically the third iteration like I mentioned above, but also the first iteration, as the second replaced the first and the third replaced the second one entirely.
2. You start with a sovereign of your selected nation and build an Empire (evil races) or Kingdom (righteous races) out of it
3. If you follow the story, you'll find out that it's actually a prequel to the Galactic Civilizations series, as the planet is Altair, the homeworld of the Altarians.
4. Your units, you design, but your heroes, you recruit and equip personally.

#39: Thwart a global alien invasion with your handful of soldiers

1. It's an hommage of a series that was big in the 90's and still gets some games out now, but unlike those who mostly played in the future, this one starts in an alternate late 70's.
2. Unlike the X-COM series, here telepathy does nothing
3. You start out with assault rifles and will go over laser to plasma weaponry later in the game 

#38: The weaponry of your character includes 19th century cavalry pistols, shotguns, a Tommy gun, a minigun, rocket launcher, quad laser and a 17th century cannon... which fires chargeable depleted uranium cannonballs Serious Sam: The First Encounter, as found by UnderwaterFunktown

1. You wander through ancient Egypt looking for a lost spaceship.
2. Many of the ennemies are actually beheaded and hold their head in one of their hands - unless they're kamikaze.

#37: When this Nintendo game was announced, very fe believed it could be a success, but it sold so well that Nintendo ended up publicly apologizing for not delivering enough copies in Japan. Splatoon, found out by drbunnig

#45

Change YoY: -3   My Rating: 9.1 / 10

The two A Plague Tale games have been among the biggest positive surprises of recent years, at least to me personally. The first game certainly looked very promising from the moment it was first revealed, but I wasn't expecting to like it as much as I did, as it was in my top 50 up until a few years ago. Then the sequel, which I finally got around to playing last year, turned out to be even better. It continues the story of Amicia, Hugo, and their friends and allies during the time of the Black Plague in France, as they begin to further unravel the truth behind the rat infestation and Hugo's powers, all the while Amicia begins to struggle more and more with her morality as the actions she must take lead her further and further down a path that will only lead to further suffering.

That internal conflict within Amicia is often at the centre of the game's story and drives many of its themes, as she desperately tries to hold on to her humanity while constantly being forced to do increasingly horrible things to survive and keep her brother safe, until eventually the question begins to emerge, is she actually being forced to do these things anymore? Charlotte McBurney's voice performance as Amicia is vital in conveying all of these aspects of the character, and had I played this game back in 2022, I would have without question considered her performance as the best of the entire year in any video game. Of course, there's more to the game than just Amicia's story.

The first game, for all its triumphs, definitely showed the limits of its budget at times. As impressive as the visuals were at times, it was still clearly an indie title, not that I really mind. Its greatest weakness was the combat, which culminated in the final boss battle that was the absolute nadir of the whole game. In the sequel, Asobo Studio has made some significant improvements in pretty much every department, or at the very least held up the high standards of the first game. Visually Requiem looks gorgeous, the gameplay has been expanded and has a lot more variety than before, and many of the locations are far more expansive and open than before, though this is still not a proper open-world game. There's really only one section in the game I found to be overly frustrating due to its instant death condition if you get caught, otherwise I enjoyed the vast majority of my experience. The soundtrack is largely of similar quality to the first game, but that just means it's great. 

Still, it is in its setting, story, and characters that A Plague Tale: Requiem truly shines. The story of the De Rune siblings against the backdrop of a nation suffering through a horrible disease is wonderfully told, and it's the seeming inevitability of tragedy that gives the game its most powerful moments, both joyful and sad, beautiful and bleak, and no moment showcases this in Requiem as well as its ending, which I will not spoil, of course. I am also very much now looking forward to the next game in the series, Resonance: A Plague Tale Legacy, though I don't quite understand why they didn't just call it A Plague Tale: Resonance. 

38) Serious Sam: The First Encounter

37) Might as well take a stab: Mario + Rabbids?