50 - Eternal Darkness
- Red > Green. Green > Blue. Blue > Red. Purple > all.
- A mature title that still remains an exclusive to a console that had a reputation for catering to younger gamers.

49
- There could be up to 4 previously unvisited countries on your itinerary.
- England, Mexico, Jamaica, Hong Kong

48 - Sonic the Hedgehog (Master System)
- Those precious collectible gemstones are found in the levels here, rather than in bonus stages like in its more powerful namesake.
- This game, starring a very well known character, was first available on both a home console and a handheld.

47 - Space Station Silicon Valley
- Robotic animals take each other out in a title from on the biggest developers out there (who were going under a different name at the time).
- A 3D puzzle platformer of sorts that first saw release on a Nintendo console, with a poorly received port later being put out on Sony hardware.

46 (incorrect guesses - Pyshconauts)
- The playable character has the ability to enter people's dreams

45
- You end up trying to solve everyone's problems whilst trying to solve your own.

44 - Metal Gear Solid
- A character in this game may make reference to other games you play, should you give them the means to do so.

43 - GoldenEye
- Several of the multiplayer modes and control schemes in this game are references to the IP the game is part of.

42
- Pink or blue - you will see one of these colours when you complete a level

41 - Super Mario 3D World
- Features a power up that will leave you feline good.

#46 - Psychonauts?

#44 - Metal Gear Solid?

#41 - Super Mario 3D World?

50. Eternal Darkness?

48. Sonic the Hedgehog (8-Bit)?

47. Space Station Silicon Valley?

44. Metal Gear Solid?

43. Goldeneye?

41. Super Mario 3D World?

50. A new IP, but a spiritual successor to a GBA spinoff of another series.

49. If you play the wrong route, you're gonna have a bad time.

48. A revival of a classic platforming series.

47. A bit of a guilty pleasure, but it is fun to mess around in this frigid world.

46. The third entry in an RPG series, released on the DS.

45. The year is 1807, and you need to make an insurance report.

44. An indie platformer where the greatest obstacle is a foot-tall barrier.

43. A roguelike strategy game IN SPACE.

42. A grand strategy game that's popular among those with spicy political leanings.

41. In 2028, a Sigma male gets kidnapped and then learns about parallel universes.

#50: Probably the best PC-exclusive fighting game there is. One Must Fall, but nobody found it out

1. Giants robots are duking it out
2. In the story mode, you can level up both your pilot and machine independently
3. There's a hyper mode that makes all the actions super-fast and combos possible that are otherwise totally impossible. Oh, and there are scrap moves that totally destroy the enemy robot.
4. One must know how to fight well in this game 
5. One must try this game, as it's freeware now.

#43: Lead your people from the Stone Age to the Space Age.

1. Unlike Civilization, this God Game is in real time
2. As a God Game, you have make some godly interventions sometimes like healing your citizens, striking UFOs with lightning strikes or protecting them under a protective dome
3. The inhabitants of the planet that you develop are called Nuggets who like Rayman don't seem to have limbs.
4. Since you're a god, the inhabitants sometimes ask you to do some godly feats for them.

#47 (Yeah I forgot that one initially, sorry): A PC pinball game with 3 tables and a horror movie level design

1. The 3 tables are called Castle, Dungeon and Laboratory
2. In the Castle multiball, the castle gate tower becomes a giant angry face with the gate becoming teeth and it constantly says "FEED ME!"
3. It's part of a Pinball series from Sierra On-Line

#40: This game series from Stardock got often called a successor to Master of Magic, here in it's third iteration.

1. It's the technically the third iteration like I mentioned above, but also the first iteration, as the second replaced the first and the third replaced the second one entirely.

#39: Thwart a global alien invasion with your handful of soldiers

49: Undertale?

46: Etrian odyssey III?

43: FTL: Faster Than Light?

42: Hearts of Iron IV?

48 might be Donkey Kong Country Returns?

And 46 - Golden Sun: Dark Dawn?

All of these are correct, although you were just edged out on Metal Gear Solid and Super Mario 3D World

All three correct!

Only 43 remains.

41) Astro Bot? :D

44) Haven't heard of the leak but Half Life 2 comes to mind