Sometimes. The "video" part of "video game" is an important factor, and if the game is an eyesore I probably will skip on it.
Also, 3D remakes of old 2D sprite-based games are something I'll skip on entirely. Good quality sprites to me will always look better than most 3D models attempting to replicate the design of the original.
I skipped the whole new generation of Monkey Island / Sam and Max games because of the ugly 3D style.
I've also skipped Ni No Kuni 2 when Ghibli was no longer involved. The hand drawn scenes were the best.