In some way, but not every game can have same effect, 3D Zelda is always huge thing, and we now have first HD, with true open and biggest world Zelda game. 3D Mario and 3D Zelda like launch titles will be pure win.
Fair enough, but a console main Pokemon would more than likely be bigger than both of those titles... Combined.
Ad a new Mario Kart and 2D Mario has a history of selling better than a 3d Mario and 3d Zelda. Just saying there are mulitple ways they could go about a launch that would equal or blow away the sales of a 3d Mario and Zelda.
Pokemon definitely would be huge, and I think because of most likely unifed platform, NX home console will have Pokemon too.
Mario Kart is one of the biggest seller for Nintendo consoles, Splatoon will become also, Smash Bros is strong seller too. But 2D Mario (or any 2D platform game) in modern gaming definitely isn't huge seller and good choice for key launch title, it has mass appealing but its not system seller, NSMBU was pretty bad choice for Wii U launch.
So what Nintendo can prepare for NX launch: MK8 and Smash Bros were released in 2014. so it would be to soon to release them in 2016. like launch title, Splatoon is 2015. game also to soon, 3D Mario World was finished in 2013. so we are on track for new 3D Mario at end of 2016, Zelda U port is basicly all but confirmed from Nintendo, Pokemon cross deavice game is also posible, and we have rumour that Namco Bandai works on Smash Bros 4 port for NX launch.