I thought maybe Uncharted could do it, but all these games that made the series a break out FF7, GTA3, COD4 were all immensly better than their previous game and Uncharted would have a hard time doing that. 

Either A.       Or C.

B.                          

And then there is D, but I doubt it will take off

Honorable mentions include

 Assassin's Creed (which we all know will take off)

LittleBigPlanet (It may take off if there is an installment on PS4)

and Nintendogs (which has already sold multi-millions)

TWEWY!!!!!!!!!!!!

jk

I wish :(

I was actually going to mention that.  I fear TWEWY is going to end up like the Chrono franchise.

No More Heroes has the potential to become a million selling franchise if launched multi-plat and added more depth.

See Iamawesome got the right idea.

Red Steel and No more Heroes are actually very good possibilities, by the time of PS4 and Xbox 3 they may have new advanced motion sensors, if it comes out early and if they can make it so its by far the most fun game to play with motion controllers like how Call of Duty 4 became the most fun to play online stomping the competition then it could easily be a break out hit.

Imagine an Online game of Death Match where you and 15 other people ran around with swords fighting one another with incredibly accurate movements, so it was like fighting a friend with a plastic sword in real life, it would require real skill to play.

Then how much fun would that be, itd be like a real life Star Wars who wouldnt buy that, if there were guns itd be like a real life Paintball. Everyone likes fighting but nobody likes getting hurt itd be away of beating people up without ending up in pain.

And then if it was to also have a really good story mode and got great reviews just like how Call of Duty 4 did then that could become the next biggest thing.

I dont see anybody topping Iamawesomes possibility. 

I really don't think FF VII was better than FF VI.

Just Dance.. You heard it here first!

I am going to go for Mass Effect for the PS4/Nextbox.  It has all the potential in the world, and with a new user base thats coming online with the PS3 I think it could explode next time.

Well the general consensus is that FF7 is one the best games ever made so its definitley above FF6 in the mainstream eyes.

A Red Steel 3 online game with PS Move/WM support and real sword movements would kick some serious ass!! Ubisoft better use that idea.

No More Heroes with Playstation Move/WM support would be good too. It could move like red steel 2. The one downside about that franchise are the odd jobs.

Dead Rising will take off as long as Capcom supports it.

As for Resistance, I doubt that franchise will take off because well, I never liked that game, and because they are starting to milk the franchise a little too much.