I was gonna start hinting only tomorrow, but... the first game on my list has never appeared on anyone's top 50, so it's hardly gonna be something everyone here knows about. That said, it has a connection with a title that has made an appearance on two prior Greatest Games Events, but not in any of those I've hosted.
#50 - This game's protagonist enters a group of hackers to try and recover an account that was stolen from him.
This sounds pretty cryptic.
To be more specific, that other game showed up in the Results of 2016 and 2017, which also were the two first years it was eligible for. It hasn't showed up since, though. This game I'm talking about it a sort-of sequel to that one.