Yes. For all intents and purposes the reboot is a self-contained side game. I really liked it and it was a lot of fun but you can avoid/ignore it if you're iun any way caring about continuity.
I'd recommend, if you're looking to prepare yourself: Tools of Destruction, Quest for Booty, A Crack in Time, Into the Nexus. Two full games, two side games. The story there is pretty consistent and fun throughout with a lot of carrying-over story beats and characters. the original trilogy/deadlocked is kind of its own thing, the future series is its own thing, and everything else is side content. I HOPE this creates a new trilogy or series on PS5, because after seeing how fun A Crack in Time is/was...well hot damn. imagine how good looking and feeling Rift Apart will be!
I personally liked Q-force/Full FRontal Assault as well as All 4 One and the PSP games (Size Matters/Secret Agent Clank), but you can skip all of them if you want. they're fun experiments (Co-op and tower defense, both fun, neither as good as the main games).
Oh I've played every game up to Tools of Destruction and then took a huge gap before playing the reboot... although I do own A Crack In Time too. What I'd need to play is Tools of Destruction as a refresher and go from there... t'would mean having to buy Quest For Booty and Nexus, although I THINK on the PS3 store if you buy Nexus digitally you get a copy of Quest For Booty too, or maybe that was just a limited time thing the last time I saw it.