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Update: The first trailer has released, confirming Alfred Molina Doc Ock, Willem Dafoe Green Goblin, and Jamie Foxx Electro, as well as the multiverse theory of the original leak. Tobey and Andrew Spider-Man remain unconfirmed, however they have been seen in both leaked set photos and leaked toys for the movie. 

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Original Story:

It was recently confirmed that Benedict Cumberbatch and Jamie Foxx would be in the movie, as Dr. Strange and Electro respectively. Now we've got some very interesting rumors about the movie and how those 2 characters will fit into it:

-Andrew Garfield and Tobey Maguire will both reprise their roles as Spider-Man

-The previous 2 Spider-Mans will show up in the movie's 3rd act, to help Tom Holland Spider-Man defeat villains from multiple Spider-Man universes who are showing up thanks to Doctor Strange's Multi-dimensional powers, which will be further expanded upon in the upcoming Doctor Strange in the Multiverse of Madness, which is set to release after MCU Spider-Man 3. One of these multi-verse villains is Electro from Amazing Spider-Man 2

-Kraven the Hunter will make his live-action debut as one of the villains in the movie, as a lead-in to his upcoming standalone movie in the Sony live-action Spider-verse

-Green Goblin will make an appearance, though it is currently unknown if it will be the Norman Osborn Green Goblin from the first Spider-Man universe played by Willem Dafoe, the Harry Osborne one from Amazing Spider-Man 2 played by Dane DeHaan, or a brand new MCU Green Goblin

-Scorpion will be making his first costumed appearance as one of the villains in the movie, after his alter-ego Mac Gargan appeared in MCU Spider-Man 2

-Nick Fury's SWORD organization will be involved with the movie

-Oscorp will make it's first MCU appearance

-Miles Morales will make his first appearance in the MCU, though we don't know if he will be one of the full fledged Spider-Mans that gets pulled in to help Tom Holland Spider-Man in the 3rd act, or if the movie will be an origin story for him within the MCU, showing how he gets his powers and setting up a future Miles Morales MCU movie

Sources:

https://www.cbr.com/spider-man-3-miles-morales-mcu-rumor/

https://fandomwire.com/spider-man-3-tobey-maguire-andrew-garfield

https://fandomwire.com/spider-man-3-villains-plot-details-revealed

Edit: Alfred Molina has now been confirmed to be returning as Doc Ock, further fueling speculation of the return of Andrew and Tobey.

Edit 2: More cast members confirmed:

Last edited by shikamaru317 - on 23 August 2021