Rockstar claims that RDR2 has 1000 voice actor cast, making it the largest ever in a game

[shikamaru317]

"Rockstar say that it used 1000 actors to flesh out the inhabitants of its towns and wilderness. Each non-player character in the world has their own personality and mood state" #RDR2 #RedDeadRedemption2 pic.twitter.com/pQMmYHQfWJ

— Michael (@LegacyKillaHD) October 2, 2018

Here is the current top 5 from what I could find:

1. Detroit: Become Human- 250

2. LA Noire- 200 

3. Fallout 4- 140

4. Bully- 130

5. Smite- 130

So, RDR2 will have a cast 4 times larger than the current #1. Absolutely crazy. The budget surely exceeds GTA V's $265m.