The way one normally holds the controller would not cause carpal tunnel or tend to impinge on any nerves causing pain. Make sure you are not sharply bending your wrist. It is more likely that a neurological condition or irritation from something else is showing up or being exacerbated by play.

You could try the following: Take aspirin or Bufferin before you play, if this prevents the pain then arthritis should be considered (regardless of age). Try varying the way you hold the controller or try the new soft sleeve. Not having to grip a hard object might help. If not you may have to take more frequent breaks but if the condition persists, I would consider seeking medical advice.

I have a similar problem and plan on suing playboy :)

 Carpal tunnel and arthritis are two ways.

My wrists and the top of my hands can hurt pretty darn bad when playing games on the PC, typing things on a keyboard, and playing a Wii-game that requires wii-mote movement.

Medic? What are we, in a warzone? lol

Hit 'E' for medic!

On topic, it's like suing for burning your lips while sipping some hot coffee. I understand wrist pain, but suing takes it too far.

Yes, the wiimote can hurt you!!

http://www.youtube.com/watch?v=nCq4Ea277Ho

You can sue for whatever you want, of course.  You won't get awarded anything, of course.  I can understand that you might spend very long periods of time playing Wii games, since the Wii games have been so amazing thus far.  That's fair, but you should take occational breaks.

Personally, I find the Wiimote much more comfortable than either my PS2 or Xbox 360 controllers although I don't have a particular problem with either of those.

@IllegalPaladin: Ok, ok Doctor, English is not my first language :(

I was just joking around, not making fun of your english. 

ok :D