The OP sounds like an American. If so, there is simply no truth to the idea that one cannot find work. It may require relocating, taking a job thats not exactly what he wants, or other sacrifice. But, in much of the US, you can drive five minutes without running into ten companies looking to hire. They may not be dream jobs. But, how many people have had to take jobs they didn't like at some point? I'm guessing its close to 100%.
And, yes, relocating is not ideal. But, tough shit. Sometimes, you have to do things that are not ideal.
When it comes to depression and the problems that brings.... well, that one is tougher. It often takes professional help to overcome, and the paradox of depression means that one has trouble getting themselves to avail themselves of that professional help. It can lead to a downward spiral. Still though, ultimately, the sufferer *must* muster the strength to get the needed help. It simply cannot be done by others.
In other cases, the depression can be solved simply by standing up, looking in the mirror, and handling your business. In this case, get yourself out of the house, get a fucking job doing anything, get some exercise, and start the ball rolling in the right direction. It spirals that way too, for many people.