There has got to be a few skill based games or precise platformers that top anything by far, I just can't think of them right now. I don't find games at all difficult these days, it's the platinum trophies where I find the real challenges. Recently MGS5's plat was insanely difficult, probably the most difficult I can remember however the games that got me sweating were the platinums for DMC RE and GOW3 RE without the glitch, The last stretch of GOW3 actully physically injured me as I kept playing for near 10 hours, drenched in sweat on a sub zero winter day without leaving the seat. So yeah, that.
Everything in the above reply is my opinion, from my own perspective and not representative of reality outside of my own head!
-Android user, please be gentle with critique on my spelling.