Probably Halo 6. They will also announce forza 7 and Ori 2. Hard to see where other new big announcements come from, but I am sure there will be at least 1 surprise.
I hope for MS sake that Crackdown 3 is not their main exclusive this year, because it screams mediocre to me. Probably will put Halo 6 beta with crackdown 3. I can see them also delaying full release Sea of Thieves to 2018 with beta end of 2017.
Cant wait to see more State of Decay 2.