First we hear the story of the wife of a blind man: they were able to play a video game together from the HD rumble and 1-2-Switch. Perhaps he even has an advantage on some of the mini games, with a honed sense of hearing and touch, or maybe she's letting him win. Either way they're playing a video game together.
Now I'll regale you with a first-hand account of holding a baby while gaming: it's made easy with the Switch's Joycons. By decoupling the controller halves, neither gameplay or arm-cradle integrity are compromised when performing both of these vital tasks simultaneously.
These are just two previously untapped markets which only the Switch can utilise. How many more paradigm shifts in gaming will we see from this wonder machine?