When you play in portable mode, does the system fit nicely in your hands?....No hand cramps?

I actually prefer it in portable mode so comfortable and looks amazing

Same as this one. It feels amazing, but I will say my hands sweat a lot with all controllers (My house is too hot, cannot control it) so I have to becareful not to hold it forever, however it feels much better the Wii U, Vita or the 3DS. 

Ik this is gonna sound weird but I like the wiiU gamepad's ergonomics better than the switch in portable mode. Because the wiiU gamepad had some stuff for my fingers to hold on to where as the Switch in portable mode is just flat.

No hand cramps here.

I have a Pro controller but I still lounge back on the sofa with the Joy-Cons separated, one arm hanging over the side and the other arm in my lap just like the old Wiimote/Nunchuck days.
So relaxing playing Zelda: BOTW like this.

And I have not experienced any Joy-Con disconnection issues yet.

ONly tried like 5 minute this morning doing something quick I thought of in bed. Got teh chest I couldnt' get earlier.

But from that quick usage, it felt 100000...% better than the 3DS does. Also it felt better imo than the joycon grip usage. I like my hands spread out like that.

Not saying joycon grip isn't great. I never once thought the controller sucked in my 6+ hours yesterday. I only have one complaint in control and that is a Zelda control scheme complaint. I want to switch the crouch button with the sprint button. Not controllers fault, games fault. You can't hold the (X or B) button while rotating the right joystick without doing some claw grip. Thus hard to rotate camera while sprinting.

Well yeah, that's why the gamepad was a giant Fisher price toy. 

OT: Better than Vita and 3DS

Not very comfortable. Holding the shoulder buttons and having to change arrows hurts my fingers. The shoulder buttons are not in a good place for me. The WiiU game pad was better yet also not great. (Fast Racing Neo cramped up my hand on that) Changing arrows with the bow drawn is the worst with them separate. It is more comfortable to play with them out of the grip, until I have to keep both shoulder buttons down.

Joy-cons aren't very joyous. Too small, connection glitches, uncomfortable button placement, tiny buttons. Too bad pro controller is over CAD 100 here, I'll deal with it. Then settle back to a nice comfy ds4 until Mario comes out.

This.  Initial impression of the Switch in portable mode is not very comfortable.  Less comfortable relative to Wii U gamepad... which you know, is not the most comfortable controller either but you can get used to it.  Much less comfortable than full size controllers like DS4/XB1.

I think in general it depends what you compare to.  Comfortable vs any other portables, not comfortable vs any other consoles.

This seems to be the most comfortable way to play.

Basically the same as using it as a controller--you're using the same Joypads. It's on par with Vita and 3DS.