Mirrors Edge and Metal Gear Solid. Both felt like really good games but they just didn't draw me in. Mirrors edge I really wanted to play as something different but I couldn't invest myself in it. MGS, i struggle with stealth play in general, but I tried to persist. However, given that its the story that usually makes me see out these games and MGS is a bit weird in this area I lost interest. While I lie open world games, it just feels empty in MGSV. Plus never understood the point of your base. You invest heavily in it but never seem to be able to do anything with it.

Deus Ex Human Revolution and Mankind Divided examples to a lesser degree. Towards the end the overbearing need for stealth and the inhibited ability to move around make the game too much of a chore and I lose interest. I'd switch to all guns blazing as the games do give you the option, but Deus Ex really seems to punish you for that as the mechanics don't really work for it.

Pokemon. I remembered having loads of fun with the original on Game Boy back in the days, but I never played any of the successors. Just some months ago, I decided to give it another go and buy Pokemon X. While I had some fun collecting Pokemon for a while, it got boring really fast. The game is just too easy for me, there's no challenge whatsoever and I don't see the point in playing it any further. I do like the characters and all, but the gameplay just isn't for me.

The Lat of Us. It seemed like a great game for what it is... but what it is... I just don't like. Too much like an interactive movie.

I tried to like Uncharted... Assassins Creed and FarCry 2, 3, 4 (I loved the first game that was made by Crytek on PC.)

Skyrim

Final Fantasy 12 & 13 - Put about eight hours into each, just couldn't stay interested.

Resident Evil (post 3) - Code Veronica had Claire doing slow-mo action movie BS and nothing else of particular interest. RE4 gameplay was okay, but the tone was completely wrong for the series. The remake of #1 was good, and 7 sounds like it might be, but Capcom almost completely killed my interest in the franchise.

Breath of Fire 5 - It's a neat concept, and it plays alright, but I just haven't been able to do one solid playthrough of it yet. I just get bored and move on.

Assassin's Creed (series) - Just can't do it. I liked Shadow of Mordor, so maybe its just a setting thing?

Legend of Zelda (post Majora's Mask) - Not sure what happened, but one of my favorite childhood series became a chore to play. The portable titles seemed weak after Links Awakening, and the home titles kept getting more bloated interest-killing tutorial intros. Never got real far in KH2 for about the same reason.

Pokemon is another I was never able to get very far into, even back when it was Blue/Red. I like the concept, and enjoyed my rental of Pokemon Snap, but that's as far as its ever gone.

Got rid of that in BOTW!

Skyward Sword is one I really had to force myself to play, but did it out of love for the franchise. I was impressed by many of the ideas in the game even if it felt like a tedious slog to work through.

I made myself play Monster Hunter 3 for some time before realising I just wasn't getting it and I wasn't having fun.

Skyrim. I tried to like it three times. The first two times I put some time into it and concluded that I was going off the Bethesda formula. I thought, perhaps, with so many open world games and mmos, Bethesda games just aren't as special anymore, but then I played Fallout 4 and it ended up my favorite game of theirs, so, convinced it was just my state of mind when I tried it, I reinstalled Skyrim, loaded it up with mods and gave it one final shot. It's just boring.

Smash bros wii U... I put time in, I read websites and watched youtube videos trying to learn how to play, I just don't get it.

Tekken... see above.

Black and White. This was a game I was hyped for and force myself to play through most of it before I finally realise that underneath this glossy ambitious game was the most tedious, poorly thought through gameplay ever. The challenge basically boils down to constantly be telling these stupid little people what to do all the time because they lack the initiative to do the most basic task without instruction.

Body Harvest... I was hyped for the idea when it was announced as an N64 launch game and I snapped it up when, many years latter, it was released. I ignored negative reviews because... well.... what do they know.... As it turned out quite a lot. Slow, messy and failing on so many levels. I know there's the idea that nintendo ruined this game but honestly there's nothing done well, be it mechanical, technical or anything.
I know I know. Surely it's not the devs fault... they made GTA... But, if they started making a good game and Nintendo tampered with it, what part of this game belonged to this fabled good game? The combate? the graphics? the controls? the SLOWWWWWW indoor sections? It's just start to finish terrible. Nintendo might well have tried their hardest to make this a worse game but the devs had already technically over stretched themselves and I recone game was always going to be a turd.

Discworld Noir. Back in the day I loved point and click adventures... I liked and respected Terry Pratchett... I put time and effort into playing this, and really tried to like it... but I didn't.

Starship Titanic. Back in the day I loved point and click adventures... I liked and respected Douglas Adams... I put time and effort into playing this, and really tried to like it... but I didn't.

Zelda the phantom hourglass... This is a rare Zelda I didn't like... But right now... ermm... I'm tired and I need to sleep. Night night

The Last Of Us. I blame the overly high expectations going into it. I kept waiting for the game to "get good" and it never did. Worth it for the story, but damn, it was a slog to play through.

Megaman series. I have tried various Megaman games, even completed one of them, which I had to drag myself through as it was frustration the entire way through. I was hoping I would learn to like it, or at least understand what is it that people like about it, but no such luck.

Zelda, Final Fantasy, Shovel Knight.