Dead Space 3, though it seems EA isn't to keen on maintaining franchises that don't fit comfortably into a certain envelope

Not true, SPM had nothing to do with the way it's sequels turned out. SS was originally a true TTYD successor, until Miyamoto came along. He alone is responsible for ruining the series.

Arkham Knight: Every time I want to go out and do some fun Batman stuff I have to spend about an hour finding a place to park my damn car.

DMC: Devil May Cry was over the top in a self aware bordeline campy kind of way. DMC was over the top in a 40 year old guy trying to appeal to 15 year olds kind of way. The gameplay was solid enough but the rest of it was so cringy I couldn't keep with it. "OMGZ the evil corporations are trying to manipulate us with their evil soda!"

Golden Sun Dark Dawn: Just incredibly meh. Nothing terrible about it, but it's just not great and after a 10 year or so wait it was majorly disappointing.

Final Fantasy 12: I haven't enjoyed a Final Fantasy game since they went away from turn based combat to a real time system. Not that I necessarily dislike rpgs with real timeish combat, but the series just hasn't done it all that well.

Mass Effect 3: Ruined is an exaggeration, but the ending left a sour taste in my mouth that's harshed my buzz for Andromeda.

Mario and Luigi Dream Team: I actually don't dislike this game or Paper Jam, but it's clear that the series is running on fumes at this point. Nintendo should just let Paper Mario take over again as the traditional RPG Mario series, and let this series take a hiatus.

Shenmue 2: Not the game itself, but the decision to put it on X-Box rather than PS2. Aside from being a slap in the face to Sega's most loyal fans, it limited the game to a small audience in the US and a nonexistent one in Japan. Even the Gamecube would have been a better home.

MGS4
Resident Evil 6
Halo 4
Gran turismo 5
Zelda twilight princess
Burnout paradise

Hmm... Shining Force Neo. Sega used a different team to make this fake Shining Force game that ruined the franchise name. It didn't have the play mechanics to be a true Shining Force.

Zelda: WW. Don't get me wrong, it's a great game. But before that there was no discussion of "art style" or "unique hook" with Zelda games. They were just one bigger and better epic adventure after another without the controversial issues that divide fans.

FFXII. The magic died when the original creators left, and this title personifies that. Possibly my favourite series essentially ended with 10 chapters.

Tony Hawk's American Wasteland started the downfall of the franchise, every entry in the series after got progressively worse and worse, culminating in the abysmal Ride and the heaping pile of hot garbage THPS5.

Nba 2k15+

I've gotten extremely pissed by how much of a money grabber it is now. 2k15 will certainly be the last nba game I'll buy for a few years.

Hmm...like some others have said, I don't consider most of these franchises to be dead permanently...but just talking as they currently stand:

Metroid Other M - Never played it, but watching my brother try it out was honestly exhausting. It was such a shame seeing this after the Prime trilogy.

Banjo: Nuts and Bolts - This game might be solid on its own...but definitely wasn't the game I was looking forward to for so long. The characters in B&K were fun...but there was much more to the first two games than what carried over into this game.

Golden Sun: Dark Dawn - Not the worst game ever...and I'd probably give it a solid 7/10...but it felt very standard in comparison to the amazing first two games. I do hope the franchise returns, but I worry that the lukewarm reception of the last entry will shelve this series for a while.

Finally...this isn't really the same...but I have zero interest in playing my old Naruto games after reading and growing to despise the manga. So in that case, you can say the source material killed my interest in the entire franchise...including games I already own.

Yes!

Mario Party 10, Island Tour, and the new Star Party... ever since 9 they just refuse to go back to what Mario Party used to be before they screwed it up.