I think that is a question Nintendo needs to look at more so than anyone else.
I loved Nintendo during the NES, SNES and N64 days and from the Gamecube, my love started to fade.
Their systems became more gimmicky, they lost third party support, they started relying on remasters, re-releases more so than any other company, the WiiU was massively overpriced compared to the features it offered (or lack of) in return, and it lacked 1st party support let alone third party.
It seems Nintendo's strategy is more about catching lightning in a bottle than delivering a quality console experience consistently. They have a good war chest in Pokemon that earns them good money and hashelped them keep afloat, as well as a dedicated fanbase that will support them through thick and thin.
Unlike Sony or even MS, Nintendo has Disney level mascots in Mario, Zelda, DK, Pokemon, Kirby etc. They have a choice to make a hugely profitable business leveraging on those IPs and cut losses or gambles on hardware or do as they are doing now.
I'm not sure what the NX will be, but it will probably cost similar to current gen consoles, it will most likely be underpowered compared to current gen consoles, and if not certainly pale next to Neo and Scorpio. It probably won't support other media and lack entertainment features, and will probably overcharge for HDD space like it did with the WiiU.
If Nintendo doesn't do well with this console / handheld, which is essentially putting all their eggs in one basket in an all in one system, it won't be about the fan boys / girls on either side, but Nintendo themselves seriously having to think about their future.
That being said, if this console can be purchased like a DIY kit, where as a console it's $250, the HH kit is $150, I think it will sell well as it will combine sales of 2 SKUs with two different audiences.