I didn't even know there was a Direct coming up to be honest. I've been so busy with all these things in my life that I'm trying to take care of. Lol XD
But with that said.
News about Twilight Princess HD, Pokken, and Star Fox should be guaranteed.
A European release date for Fire Emblem Fates should be expected along with one final trailer and amiibo support.
Some updates regarding Genei Ibun Roku #FE.
I'd also like a Bravely Second trailer.
They'll mention the 20th Anniversary of Pokémon and touch up on some things like Pokémon GO, as well as officially announce what we all expect, Pokémon Z.
An announcement of the announcement of NX would be great too. And if we're lucky, they'll cap it off with a trailer for Zelda Wii U. Seems very unlikely though.