-Pokemon Z, that one is obvious.
-EarthBound compilation. The three Mother games in one cartridge.
-Something for the N3DS, to justify its existence.

Also, a retail release of Detective Pikachu might come too. And if Undertale comes to the 3DS, it will have a retail release too, it's too hot right now to not have it.

Xenoblade X 3ds
Bayonetta 3ds
Mario Maker 3ds.

Splatoon 3DS
Mario Maker 3DS
Pokémon Z

Pokemon Red
Pokemon Green
Pokemon Blue

All remakes :D

Pokemon Z
Pokemon Rangers game
Zelda Game

reminder this year is the 20th anniversary of Pokemon and 30th anniversary of Zelda

I have always thought there would be a Super Mario 3D Land 2, but figured it wouldn't happen anymore by now due to the system being on it's last legs... However, with these new comments of high profile games still coming I guess that's back on the table, kind of. So I'll say;

Super Mario 3D Land 2
SNES Remix
Metroid 5 (one can hope)

And likely Pokémon Z indeed, since it's the series' 20th this year.

Pokémon X2 Y2 (It's not Z, and, since we only have one main Zygarde form announced as of now, it's more likely to be one sequel instead of two :p ) ;
2D Metroid game that'll replace Federation Force's co-op mode, Blast Ball will remain part of the package or become an E-shop only title.
Moar Pokémon VC (today Red/Blue Team MD games were announced), probably Ranger