The best advise has already been given, seek professional help. Good luck to you.

 If nothing in your life is the cause for it than it's probably a chemical imbalance. You should see a phychiatrist in that case. He/she will figure out it's severity and probably use medication to treat the depression. 

Can you live with your mistakes and remorse ? 

Can and do you want to go back to the way things were and pretend that none of what you did ever happened ? 

Can you still keep going on with life in your current condition ? 

These will be the last set of questions ...

You're not alone with what you're going through and you don't have to deal with it quietly on your own.
Go and seek out help. Depression is a serious illness, that can have various diffrent reasons. Sometimes it's something physical, a chemical imbalance in your brain, sometimes it's something mental, some sort of trauma you haven't overcome. It might seem trivial at first even to you, but it keeps on hurting you.
Try and get help. Try and get an official diagnosis if you haven't done so already and put a name to your condition.
Then work on fixing it.
Whatever it is you can get there. Just go at your own pace and remember that you are in control of your own life. Sometimes that means hard decisions.

first get your love life in order... your probably just using the new girl.. dump her.. make closure with your wife..
then do something for yourself .. do sports.. run.. walk whatever.. create a time for yourself, I do all my selfreflection while doing sports...

then we talk again.. you'll have to do this step by step..we ain't gonna solve this in an hour..

Hey man.. d21lewis and I got someone to man up and got Married on this forum.. we're the best!

Has there been an important life event that you think could've triggered the emptiness feel? There are so many questions but the last thing I want you to think is that you're being judged. I wish I could help you, but this might be something professional help can solve. Depression is never a joke; at some point we've all been there.

her or your job title is meaningless, its shit peopel hide behind.  A job title does not make who you are nor does it make you happy.  Maybe she was good at pretanding its all that but really its quite meaningless.

What makes me well me gave me no titles no finencial gain, i blew mopre then half decade of strickely persuing something that due to injury did not pan out.

But it made me who i am, build my confidence taught me about the world and how full of bs it really is.  It build me into a lion that can handle all the crap the world throws at him and smile back at the bastard that is fate that is constantly fucking with me.  

What did or still do you want to do ?????untill you figure out what that is and go for it you will never be really happy or satisfied ot even content.  It can be anything crazy or hard, as long as its your truely.  

i'm sorry but i'm gonna be very straight to you. You should feel proud of your wife achievements and instead you start to push her away? that is not how a proper man behaves. My wife has a more successful professional life than me and all i can feel is proud that she can do what she does and i feel a little better about myself because in the relationship i do my small part that helps her achieve what she does right now and what she will in the future (and i know i could do a lot more, but i'am lazy, still i try to give at least a stable relationship and a funny and light home environment (yes, my job is to tell her jokes)). As long as she doesn't feel i holding her back, this situation does not bother me, i work for money (i'm a wore) not for social recognition, i am what i am not what i do. This is the 21 century, don't let  old prejudice mess up your life.

Man up is my advice. Happiness is overrated afterall...
Also seek professional help because with health one should not joke about. And a hobby besides gaming, if it involves physical activity even better. my advice is swimming, while you are in the water you think of nothing and you feel weightless.

Considering you already got the responses you needed (what sergiodaly said and professional help) i'll just tell you to go here for now:
https://www.google.bg/search?q=kittens&espv=2&biw=1280&bih=641&source=lnms&tbm=isch&sa=X&ei=rymVVZvrO4SZsgHBuKuwBA&ved=0CAYQ_AUoAQ