Halo 5 and 6, and a huge huge maybe for Gears of Wars 4 for XB1.

Uncharted 4 (Another maybe, but a lesser one) The last of us 2, and GT7 for the PS4.

Mario Kart 8 (I'm being a bit generous here, but I think it has a chance) for the Wii U.

in my opinion only ps4 exclusives will achieve this if ever someone besides the 3ds is going to

Halo 5 don't will break 10,000,000... it will be lucky with 9,000,000. And Gran Turismo after the massive decline of the sixth, i'm not sure if will ever comeback.
Any way, the next Pokémon, Mario Kart 8, The Last of us 2, and maybe other.

Uncharted 4: A Thief's End
The Last of Us 2
GT7

Gran Turismo 7 (I have high hopes that this will reverse the decline from 6)
Halo 5/6
New Super Mario Bros. 2
TLOU 2 (it's nearly sold 10 million on the PS3 dammit, because Sony announced 7 million sold back in July 2014)
Possibly Uncharted 4

That's it really.

Does Smash 3DS/WiiU combined count?

I came in here guessing 3.... ignoring handhelds of course.
Gran Turismo 7 - GT6 on PS3 was a fucking stupid idea, GT7 will be a return to form.
Halo - Not entirely sure on this one but its done it before.
Uncharted 4/The Last of Us 2 - Really all Im saying is Naughty Dog should get their once this gen. Maybe twice, means Im not relying on Halo to get there.

Lotta people calling for TLOU 2! You guys know something I don't?

Halo 5
The Last of Us 2
Mario
Gran turismo 7 or 8

Ha, care to prove anyting using not made up foolishness.