So most people seem to agree that the 3DS successor will release in the next couple years, I would say Spring 2016 at the earliest and Spring 2017 at the latest. If this time frame ends up being correct, what will the big launch titles be?
3DS had a pretty poor launch window, the biggest launch title was Nintendogs+Cats and went on to have a pretty big drought where Ocarina of Time 3D was the only big release for about 6 months. That on top on a high launch price really hurt early 3DS sales. If Nintendo wants their next handheld to come out with a bang, they will need a strong launch window.
I think the next handheld will release in Q2/Q3 2016 with Animal Crossing and Luigi's Mansion 3 as the big launch titles.
When the herd loses its way, the shepard must kill the bull that leads them astray.