I imagine we're well past the possibility of a single game doing it, especially since the industry seems to be splintered into three sizeable sets of core gamer, and a few other groups that are healthy enough in size; the big ones currently being a Nintendo centric handheld core (3DS), a third-party centric home-console core (PS4), and an online retail centric PC core (Steam). Even beyond that all three groups have a major provider (Nintendo, console centric third-parties, and PC centric studios) and countless smaller agents (indies).

Its easy to say the industry is indestructible, but is anything really indestructible? - I want to hear your doomsday scenarios, where the PSP-Morte and the Ultra NES can't take over if the current models fail, and where PC gaming also becomes unsustainable.

(This came to my mind after I made a joke about Destiny being the new ET and Captain Toad being the new Mario.)

Nintendo, Sony and MS going bankrupt and EA being the last one standing should pretty much do it

And in what scenario could you imagine them all going bankrupt simultaniously, and how would it kill the PC third?

Replace MS with Valve, or put both in for good measure.

This will cause the industry to get really close to crashing.

Makes sense to me, MS and Valve both gone means no new Windows gaming and no Steam OS.

But how do you envision that happening?

Google takes over the world with Chrome OS.

Easy. MICROSOFT BUYING NINTENDO, SONY, AND VALVE!

And prove Link and Nathan stole all the money Big N and Sony made from them by monitoring them slightly more than Microsoft? (Link is sooo much more of a kleptomaniac than Drake, but like a clever one he hides it in plain sight.) 

I can't cut down quote trees on mobile, sorry.

Ninty can go bankrupt because filthy casuals prefer mobile gaming.

Sony will go bankrupt if their PS division underperforms and their Insurance arm underperforms. Oh, and their Xperia line underperforms!

Don't forget them buying all the big third-party publishers!