http://plebegaming.wordpress.com/2014/07/26/upcoming-uses-for-the-wii-u-game-pad/
One of the Wii U's biggest failures has been the failure to illustrate why the game pad is really needed. There are some games that use it well, W101 and Zombi U being the most notable, but there's not enough there to really sell a system on. So what uses could you come up with, or what would really appeal to you?
I personally want more of the asymmetrical gameplay that's planned for Mario Party 10, but in a series I'd care more about.
As for what's the best for sales though, it's hard to go wrong with the amiibo. I had no idea how big Skylanders was, and that series was made from scratch. With a ready made audience for amiibo, the numbers could get ridiculous very fast.