ummm lots....

Sonic
Sonic 2
Sonic 3
Quack Shot
Spiderman and venom maximum carnage
spiderman and venom separation anxiety
Road Rash II
Battletoads&Double Dragon:The ultimate team
mighty morphin power rangers (gens)
beavis and butthead (gens)

Marvel Vs. Capcom
Marvel Vs Capcom 2
Soul Calibur
Soul Calibur 2

Megaman 8
Megaman Legends
Megaman X4

Metal Gear Solid 4
Uncharted 2
Uncharted 3
Tekken Tag Tournament 2, which I've played more than any game, exept MvC2.

Quite some. Most are construction/simulation games as they are naturally endless. Even though usually, except Anno 1404, they don't track time I know for sure I've topped 100 hours in these games, possibly even up to tenfold on some like Anno 1602 and Galactic Battlegrounds. A couple are even more. If I'd guess my hours on both SimCity 4 and Rollercoaster Tycoon 2, I'd say it's probably up to about 4-5000 hours. Though those four are by far the highest. At at least a hundred hours are:

Anno 1404 (Dawn of Discovery)
Anno 1602 (1602 A.D.)
Call of Duty
Guitar Hero III
Mario Kart 64
Medieval: Total War
Pokémon Blue
Rollercoaster Tycoon 2
Rome: Total War
SimCity 3000
SimCity 4
Sim Tower
Star Wars: Galactic Battlegrounds
Theme Hospital

Plus, if you combine playthroughs or different versions, I've also got over 100 hours on these:

The Legend of Zelda: Ocarina of Time
The Legend of Zelda: Twilight Princess
Star Wars: Knights of the Old Republic
Star Wars: Knights of the Old Republic II
Super Mario 64

Pokémon White and Pokémon X